Parvocellulaire neurosecretoire cel

Parvocellulaire neurosecretoire cellen zijn kleine zenuwcellen die door de hypothalamus-afgevende en remmende hormonen produceren. De cellichamen van deze zenuwcellen bevinden zich in verschillende kernen van de hypothalamus of in nauw verwante gebieden van de basale hersenen, voornamelijk in de mediale zone van de hypothalamus. Alle of de meeste axonen van de parvocellulaire neurosecretoire cellen projecteren naar de mediane eminentie, aan de basis van de hersenen, waar hun zenuwuiteinden de hypothalamische hormonen vrijgeven. Deze hormonen worden vervolgens onmiddellijk opgenomen in de bloedvaten van de hypofysepoortader, die ze naar de hypofysevoorkwab transporteren, waar ze de afscheiding van hormonen in de systemische circulatie reguleren.

Typen[bewerken | brontekst bewerken]

De parvocellulaire neurosecretoire cellen produceren het volgende:

Thyreotropinevrijmakend hormoon (TRH), dat fungeert als de primaire regulator van thyreoïdstimulerend hormoon (TSH) en een regulator van prolactine^[1]
Corticotropin-releasing hormone (CRH), dat fungeert als de primaire regulator van corticotropine (ACTH)^[2]^[3]^[4]^[5]^[6]
Neurotensine, dat fungeert als een regulator van het luteïniserend hormoon en prolactine^[3]^[7]

Bronnen, noten en/of referenties

↑ Ghamari-Langroudi, M., Vella, K. R., Srisai, D. (13 October 2010). Regulation of Thyrotropin-Releasing Hormone-Expressing Neurons in Paraventricular Nucleus of the Hypothalamus by Signals of Adiposity. Molecular Endocrinology 24 (12): 2366–2381. PMID 20943814. PMC 2999480. DOI: 10.1210/me.2010-0203.
↑ Lennard, DE, Eckert, WA, Merchenthaler, I (April 1993). Corticotropin-releasing hormone neurons in the paraventricular nucleus project to the external zone of the median eminence: a study combining retrograde labeling with immunocytochemistry.. Journal of Neuroendocrinology 5 (2): 175–81. PMID 8485552. DOI: 10.1111/j.1365-2826.1993.tb00378.x.
↑ ^a ^b Sawchenko, PE, Swanson, LW, Vale, WW (March 1984). Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat.. Proceedings of the National Academy of Sciences of the United States of America 81 (6): 1883–7. PMID 6369332. PMC 345027. DOI: 10.1073/pnas.81.6.1883.
↑ Horn, A. M., Robinson, I. C. A. F., Fink, G. (1 February 1985). Oxytocin and vasopressin in rat hypophysial portal blood: experimental studies in normal and Brattleboro rats. Journal of Endocrinology 104 (2): 211–NP. PMID 3968510. DOI: 10.1677/joe.0.1040211.
↑ Freeman, ME, Kanyicska, B, Lerant, A (October 2000). Prolactin: structure, function, and regulation of secretion.. Physiological Reviews 80 (4): 1523–631. PMID 11015620. DOI: 10.1152/physrev.2000.80.4.1523.
↑ Johnston, CA, Negro-Vilar, A (January 1988). Role of oxytocin on prolactin secretion during proestrus and in different physiological or pharmacological paradigms.. Endocrinology 122 (1): 341–50. PMID 3335212. DOI: 10.1210/endo-122-1-341.
↑ Watanobe, H, Takebe, K (April 1993). In vivo release of neurotensin from the median eminence of ovariectomized estrogen-primed rats as estimated by push-pull perfusion: correlation with luteinizing hormone and prolactin surges.. Neuroendocrinology 57 (4): 760–4. PMID 8367038. DOI: 10.1159/000126434.

[1] Ghamari-Langroudi, M., Vella, K. R., Srisai, D. (13 October 2010). Regulation of Thyrotropin-Releasing Hormone-Expressing Neurons in Paraventricular Nucleus of the Hypothalamus by Signals of Adiposity. Molecular Endocrinology 24 (12): 2366–2381. PMID 20943814. PMC 2999480. DOI: 10.1210/me.2010-0203.

[2] Lennard, DE, Eckert, WA, Merchenthaler, I (April 1993). Corticotropin-releasing hormone neurons in the paraventricular nucleus project to the external zone of the median eminence: a study combining retrograde labeling with immunocytochemistry.. Journal of Neuroendocrinology 5 (2): 175–81. PMID 8485552. DOI: 10.1111/j.1365-2826.1993.tb00378.x.

[Sawchenko-3] Sawchenko, PE, Swanson, LW, Vale, WW (March 1984). Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat.. Proceedings of the National Academy of Sciences of the United States of America 81 (6): 1883–7. PMID 6369332. PMC 345027. DOI: 10.1073/pnas.81.6.1883.

[horn-4] Horn, A. M., Robinson, I. C. A. F., Fink, G. (1 February 1985). Oxytocin and vasopressin in rat hypophysial portal blood: experimental studies in normal and Brattleboro rats. Journal of Endocrinology 104 (2): 211–NP. PMID 3968510. DOI: 10.1677/joe.0.1040211.

[freeman-5] Freeman, ME, Kanyicska, B, Lerant, A (October 2000). Prolactin: structure, function, and regulation of secretion.. Physiological Reviews 80 (4): 1523–631. PMID 11015620. DOI: 10.1152/physrev.2000.80.4.1523.

[6] Johnston, CA, Negro-Vilar, A (January 1988). Role of oxytocin on prolactin secretion during proestrus and in different physiological or pharmacological paradigms.. Endocrinology 122 (1): 341–50. PMID 3335212. DOI: 10.1210/endo-122-1-341.

[7] Watanobe, H, Takebe, K (April 1993). In vivo release of neurotensin from the median eminence of ovariectomized estrogen-primed rats as estimated by push-pull perfusion: correlation with luteinizing hormone and prolactin surges.. Neuroendocrinology 57 (4): 760–4. PMID 8367038. DOI: 10.1159/000126434.

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