Oxidoreductase

Oxidoreductasen zijn enzymen die redoxprocessen katalyseren. Redoxprocessen zijn processen waarbij door elektronenoverdracht één van de atoomsoorten wordt geoxideerd en een ander gereduceerd. Oxidatie is het proces waarbij elektronen worden afgestaan en reductie is het proces waarbij elektronen worden opgenomen. Acteert op de CH-OH groep van donoren (= reductor) met NAD+ of NADP+ als elektronen-accepteerder (= oxidator).

Tot de groep oxidoreductasen behoren de hydrogenasen, oxidasenreductasen, transhydrogenasen en hydroxylasen.

Bij de mens (Homo sapiëns) zijn er ± 154 oxidoreductasen bekend (werkzaam in het lichaam).

Classificatie [bewerken]

EC-nummer:	Functie:	Naam:	Homo sapiëns
1.1.1.1	Alcohol + NAD⁺ $\rightleftharpoons$ Aldehyde of Keton + NADH + H⁺	Alcoholdehydrogenase (NAD⁺)	Ja
1.1.1.2	Alcohol + NADP⁺ $\rightleftharpoons$ Aldehyde + NADPH + H⁺	Alcoholdehydrogenase (NADP⁺)	Ja
1.1.1.3	L-Homoserine + NAD(P)⁺ $\rightleftharpoons$ L-aspartaat 4-semialdehyde + NAD(P)H + H⁺	Homoserinedehydrogenase
1.1.1.4	(R,R)-butaan-2,3-diol + NAD⁺ $\rightleftharpoons$ (R)-Acetoïne + NADH + H⁺	(R,R)-butaanedioldehydrogenase
1.1.1.5	Acetoïne + NAD⁺ $\rightleftharpoons$ Diacetyl + NADH + H⁺	Acetoïnedehydrogenase
1.1.1.6	Glycerol + NAD⁺ $\rightleftharpoons$ Glycerone + NADH + H⁺	Glyceroldehydrogenase
1.1.1.7	Propaan-1,2-diol 1-fosfaat + NAD⁺ $\rightleftharpoons$ Hydroxyaceton-fosfaat + NADH + H⁺	Propaandiol-fosfaatdehydrogenase
1.1.1.8	Tin-Glycerol 3-fosfaat + NAD⁺ $\rightleftharpoons$ Glycerone fosfaat + NADH + H⁺	Glycerol-3-fosfaatdehydrogenase (NAD⁺)	Ja
1.1.1.9	Xylitol + NAD⁺ $\rightleftharpoons$ D-xylulose + NADH + H⁺	D-xylulose reductase
1.1.1.10	Xylitol + NADP⁺ $\rightleftharpoons$ L-xylulose + NADPH + H⁺	L-xylulose reductase	Ja
1.1.1.11	D-arabinitol + NAD⁺ $\rightleftharpoons$ D-xylulose + NADH + H⁺	D-arabinitol 4-dehydrogenase
1.1.1.12	L-arabinitol + NAD⁺ $\rightleftharpoons$ L-xylulose + NADH + H⁺	L-arabinitol 4-dehydrogenase
1.1.1.13	L-arabinitol + NAD⁺ $\rightleftharpoons$ L-ribulose + NADH + H⁺	L-arabinitol 2-dehydrogenase
1.1.1.14	L-iditol + NAD⁺ $\rightleftharpoons$ L-sorbose + NADH + H⁺	L-iditol 2-dehydrogenase	Ja
1.1.1.15	D-iditol + NAD⁺ $\rightleftharpoons$ D-sorbose + NADH + H⁺	D-iditol 2-dehydrogenase
1.1.1.16	Galactitol + NAD⁺ $\rightleftharpoons$ D-tagatose + NADH + H⁺	Galactitol 2-dehydrogenase
1.1.1.17	D-mannitol 1-fosfaat + NAD⁺ $\rightleftharpoons$ D-fructose 6-fosfaat + NADH + H⁺	D-Mannitol-1-fosfaat 5-dehydrogenase
1.1.1.21		aldehyde reductase	Ja
1.1.1.22		UDP-glucose 6-dehydrogenase	Ja
1.1.1.27		L-lactate dehydrogenase	Ja
1.1.1.30		3-hydroxybutyrate dehydrogenase	Ja
1.1.1.31		3-hydroxyisobutyrate dehydrogenase	Ja
1.1.1.34		hydroxymethylglutaryl-CoA reductase (NADPH)	Ja
1.1.1.35		3-hydroxyacyl-CoA dehydrogenase	Ja
1.1.1.37		malate dehydrogenase	Ja
1.1.1.38		malate dehydrogenase (oxaloacetate-decarboxylating)	Ja
1.1.1.40		malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)	Ja
1.1.1.41		isocitrate dehydrogenase (NAD+)	Ja
1.1.1.42		isocitrate dehydrogenase (NADP+)	Ja
1.1.1.44		phosphogluconate dehydrogenase (decarboxylating)	Ja
1.1.1.45		L-gulonate 3-dehydrogenase	Ja
1.1.1.47		glucose 1-dehydrogenase	Ja
1.1.1.49		glucose-6-phosphate dehydrogenase	Ja
1.1.1.50		3alpha-hydroxysteroid dehydrogenase (B-specific)	Ja
1.1.1.62		estradiol 17beta-dehydrogenase	Ja
1.1.1.63		testosterone 17beta-dehydrogenase	Ja
1.1.1.64		testosterone 17beta-dehydrogenase (NADP+)	Ja
1.1.1.79		glyoxylate reductase (NADP+)	Ja
1.1.1.81		hydroxypyruvate reductase	Ja
1.1.1.95		phosphoglycerate dehydrogenase	Ja
1.1.1.100		3-oxoacyl-(acyl-carrier-protein) reductase	Ja
1.1.1.102		3-dehydrosphinganine reductase	Ja
1.1.1.105		retinol dehydrogenase	Ja
1.1.1.112		indanol dehydrogenase	Ja
1.1.1.141		15-hydroxyprostaglandin dehydrogenase (NAD+)	Ja
1.1.1.145		3beta-hydroxy-DELTA5-steroid dehydrogenase	Ja
1.1.1.146		11beta-hydroxysteroid dehydrogenase	Ja
1.1.1.149		20alpha-hydroxysteroid dehydrogenase	Ja
1.1.1.153		sepiapterin reductase	Ja
1.1.1.170		sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)	Ja
1.1.1.178		3-hydroxy-2-methylbutyryl-CoA dehydrogenase	Ja
1.1.1.179		D-xylose 1-dehydrogenase (NADP+)	Ja
1.1.1.181		cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase	Ja
1.1.1.184		carbonyl reductase (NADPH)	Ja
1.1.1.188		prostaglandin-F synthase	Ja
1.1.1.189		prostaglandin-E2 9-reductase	Ja
1.1.1.197		15-hydroxyprostaglandin dehydrogenase (NADP+)	Ja
1.1.1.205		IMP dehydrogenase	Ja
1.1.1.211		long-chain-3-hydroxyacyl-CoA dehydrogenase	Ja
1.1.1.213		3alpha-hydroxysteroid dehydrogenase (A-specific)	Ja
1.1.1.225		chlordecone reductase	Ja
1.1.1.263		1,5-anhydro-D-fructose reductase	Ja
1.1.1.270		3-keto-steroid reductase	Ja
1.1.1.271		GDP-L-fucose synthase	Ja
1.1.1.284		S-(hydroxymethyl)glutathione dehydrogenase	Ja
1.1.1.300		NADP-retinol dehydrogenase	Ja
1.1.2.4		D-lactate dehydrogenase (cytochrome)	Ja
1.1.3.15		(S)-2-hydroxy-acid oxidase	Ja
1.1.4.1		vitamin-K-epoxide reductase (warfarin-sensitive)	Ja
1.1.5.3		glycerol-3-phosphate dehydrogenase	Ja
1.1.99.1		choline dehydrogenase	Ja
1.1.99.2		2-hydroxyglutarate dehydrogenase	Ja
1.1.99.24		hydroxyacid-oxoacid transhydrogenase	Ja
1.2.1.3		aldehyde dehydrogenase (NAD+)	Ja
1.2.1.5		aldehyde dehydrogenase NAD(P)+	Ja
1.2.1.8		betaine-aldehyde dehydrogenase	Ja
1.2.1.12		glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	Ja
1.2.1.18		malonate-semialdehyde dehydrogenase (acetylating)	Ja
1.2.1.19		aminobutyraldehyde dehydrogenase	Ja
1.2.1.24		succinate-semialdehyde dehydrogenase	Ja
1.2.1.27		methylmalonate-semialdehyde dehydrogenase (acylating)	Ja
1.2.1.31		L-aminoadipate-semialdehyde dehydrogenase	Ja
1.2.1.36		retinal dehydrogenase	Ja
1.2.1.41		glutamate-5-semialdehyde dehydrogenase	Ja
1.2.1.47		4-trimethylammoniobutyraldehyde dehydrogenase	Ja
1.2.1.50		long-chain-fatty-acyl-CoA reductase	Ja
1.2.3.1		aldehyde oxidase	Ja
1.2.4.1		pyruvate dehydrogenase (acetyl-transferring)	Ja
1.2.4.2		oxoglutarate dehydrogenase (succinyl-transferring)	Ja
1.2.4.4		3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)	Ja
1.3.1.2		dihydropyrimidine dehydrogenase (NADP+)	Ja
1.3.1.3		DELTA4-3-oxosteroid 5beta-reductase	Ja
1.3.1.10		enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)	Ja
1.3.1.20		trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Ja
1.3.1.21		7-dehydrocholesterol reductase	Ja
1.3.1.24		biliverdin reductase	Ja
1.3.1.34		2,4-dienoyl-CoA reductase (NADPH)	Ja
1.3.1.38		trans-2-enoyl-CoA reductase (NADPH)	Ja
1.3.1.48		15-oxoprostaglandin 13-oxidase	Ja
1.3.1.70		DELTA14-sterol reductase	Ja
1.3.1.72		DELTA24-sterol reductase	Ja
1.3.1.74		2-alkenal reductase	Ja
1.3.3.3		coproporphyrinogen oxidase	Ja
1.3.3.4		protoporphyrinogen oxidase	Ja
1.3.3.6		acyl-CoA oxidase	Ja
1.3.5.1		succinate dehydrogenase (ubiquinone)	Ja
1.3.5.2		dihydroorotate dehydrogenase	Ja
1.3.99.2		butyryl-CoA dehydrogenase	Ja
1.3.99.3		acyl-CoA dehydrogenase	Ja
1.3.99.5		3-oxo-5alpha-steroid 4-dehydrogenase	Ja
1.3.99.7		glutaryl-CoA dehydrogenase	Ja
1.3.99.10		isovaleryl-CoA dehydrogenase	Ja
1.3.99.13		long-chain-acyl-CoA dehydrogenase	Ja
1.3.99.23		all-trans-retinol 13,14-reductase	Ja
1.4.1.3		glutamate dehydrogenase NAD(P)+	Ja
1.4.1.21		aspartate dehydrogenase	Ja
1.4.3.1		D-aspartate oxidase	Ja
1.4.3.2		L-amino-acid oxidase	Ja
1.4.3.3		D-amino-acid oxidase	Ja
1.4.3.4		monoamine oxidase	Ja
1.4.3.5		pyridoxal 5'-phosphate synthase	Ja
1.4.3.13		protein-lysine 6-oxidase	Ja
1.4.3.21		primary-amine oxidase	Ja
1.4.3.22		diamine oxidase	Ja
1.4.4.2		glycine dehydrogenase (decarboxylating)	Ja
1.5.1.2		pyrroline-5-carboxylate reductase	Ja
1.5.1.3		dihydrofolate reductase	Ja
1.5.1.5		methylenetetrahydrofolate dehydrogenase (NADP+)	Ja
1.5.1.6		formyltetrahydrofolate dehydrogenase	Ja
1.5.1.8		saccharopine dehydrogenase (NADP+, L-lysine-forming)	Ja
1.5.1.9		saccharopine dehydrogenase (NAD+, L-glutamate-forming)	Ja
1.5.1.12		1-pyrroline-5-carboxylate dehydrogenase	Ja
1.5.1.15		methylenetetrahydrofolate dehydrogenase (NAD+)	Ja
1.5.1.20		methylenetetrahydrofolate reductase NAD(P)H	Ja
1.5.1.30		flavin reductase	Ja
1.5.1.34		6,7-dihydropteridine reductase	Ja
1.5.3.1		sarcosine oxidase	Ja
1.5.3.7		L-pipecolate oxidase	Ja
1.5.3.13		N1-acetylpolyamine oxidase	Ja
1.5.3.16		spermine oxidase	Ja
1.5.5.1		electron-transferring-flavoprotein dehydrogenase	Ja
1.5.99.1		sarcosine dehydrogenase	Ja
1.5.99.2		dimethylglycine dehydrogenase	Ja
1.5.99.8		proline dehydrogenase	Ja
1.6.1.2		NAD(P)+ transhydrogenase (AB-specific)	Ja
1.6.2.2		cytochrome-b5 reductase	Ja
1.6.2.4		NADPH-hemoprotein reductase	Ja
1.6.3.1		NAD(P)H oxidase	Ja
1.6.5.2		NAD(P)H dehydrogenase (quinone)	Ja
1.6.5.3		NADH dehydrogenase (ubiquinone)	Ja
1.6.5.5		NADPH:quinone reductase	Ja
1.6.99.3		NADH dehydrogenase	Ja
1.7.1.7		GMP reductase	Ja
1.8.1.4		dihydrolipoyl dehydrogenase	Ja
1.8.1.7		glutathione-disulfide reductase	Ja
1.8.1.8		protein-disulfide reductase	Ja
1.8.1.9		thioredoxin-disulfide reductase	Ja
1.8.3.1		sulfite oxidase	Ja
1.8.3.2		thiol oxidase	Ja
1.8.3.5		prenylcysteine oxidase	Ja
1.8.4.2		protein-disulfide reductase (glutathione)	Ja
1.8.4.B3		thioredoxin-independent methionine sulfoxide reductases B	Ja
1.8.4.11		peptide-methionine (S)-S-oxide reductase	Ja
1.8.4.12		peptide-methionine (R)-S-oxide reductase	Ja
1.8.98.2		sulfiredoxin	Ja
1.9.3.1		cytochrome-c oxidase	Ja

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Oxidoreductase

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