Gebruiker:Wybe/Kladblok1

Oscar Kuipers
Persoonlijke gegevens
Geboortedatum	12-05-1956
Geboorteplaats	Rotterdam
Nationaliteit	Nederlands
Wetenschappelijk werk
Vakgebied	Molecular genetics Micro Biology Biotechnology
Alma mater	Utrecht University
[Staff page officiële website]

Prof. Dr. Oscar P. Kuipers (Rotterdam, May 12 1956) is a Dutch professor molecular genetics of the University of Groningen (UG). His areas of expertise include among more Microbiology, Biochemistry & Molecular and cell biology and Biotechnology.

Study and career

• Kuipers graduated in 1986 in biology at Utrecht University.
• In 1988 Kuipers obtained a EMBO Fellowship for three month at the lab of Dr. J. Gallay of the University of Paris-Sud in Orsay (Paris) to study time-resolved Fluorescence.
• In 1989 Kuipers received a SHELL fellowship to give lectures in the United States at Prof. Mahendra Jain (Newark), Prof. Michael Gelb (Seattle) and Prof. Yang (San Francisco) and on a conference about Time Resolved Fluorescence.
• In 1990 Kuipers obtained his doctorate at the University of Utrecht in biochemistry with the thesis Probing the mechanism of pancreatic phospholipase A2 by protein engineering.
• From 1990 to 1997 he worked as a project leader on molecular genetics at the Department of Biophysical Chemistry of NIZO food research, a contract research center in Ede (The Netherlands).
• From 1997 to 1999 he was head of genetics and research leader of the section Microbial Ingredients of the same institute.
• From 1999 Kuipers is professor and head of the ‘Molecular Genetics of Prokaryotes’ group of the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) of the University of Groningen.

Honours and Awards

• 2015 Elected Board Member, European Academy of Microbiology (EAM)
• 2013 Elected Member, European Academy of Microbiology (EAM)
• 2012 iGEM Team Groningen: European and World Champion 2012 (Kuipers was supervisor/coach/coordinator of the iGEM team Groningen from 2008-2015)
• 2011 Elected Member, Royal Netherlands Academy of Arts and Sciences (KNAW)
• 2011 Simon Stevin Meester Award (Science and Technology Award of STW, NWO, the Netherlands) €500,000

Administrative and Management functions

• 1999 – 2000 member of the founding committee of the Groningen Genomics Centre of the University of Groningen
• 1999 – 2007 Member of the Board of directors of the Groningen Biomolecular Sciences and Biotechnolgy Institute (GBB) of the University of Groningen
• 2000 – 2007 Chairman of the Genetics Cluster of the University of Groningen
• 2011 – present Member of the scientific advisory board of the LOEWE Institute for Synthetitic Microbiology (Synmikro) in Marburg (Germany)
• 2013 – present Confidential advisor on scientific integrity, Faculty of Mathematics- and Natural Sciences, University of Groningen Groningen
• 2015 – present Chairman and co-founder of the Centre for Sustainable Antimicrobials (CeSAM) of the University of Groningen
• 2015 – present cofounder, Centre for Antimicrobial Research (CARES). Chairman & Director: Prof. Gilles van Wezel.

Research

The research of Kuipers and his research group is focused on curiosity driven research with a keen eye on biotechnological applicationsBasic research Kuipers files19 patents and has sofar supervised 21 postdoctoral_researchers en 35 PhD students Doctors of Philosophy in their doctorate research. At the moment (October 2015) he supervises 18 PhD studentsPhD’s and 7 Postdoctoral researchers. He has been invited more than 180 times to national or international conferences and seminars Congresses to give a lecture.

An important topic of research is the study of the genetics and fysiology of bacteria. Among others the cellular differentiation of bacteria is investigated. Bacteria growing in a culture can develop different characteristics, while their genome remains unchanged. Kuipers: ‘Our research has many applications, for example the improvement of protein production in industrial fermentation'. An other important subject is the production and modification of peptides peptides. These modified peptides (lantibiotics), are made by bacteria, and can serve as antibiotic. Modified peptides are chemically more stable and retain their function longer than unmodified peptides. This is beneficial for medical applications as a novel class of antibiotics. Further areas of focus are the molecular biology of: competence, sporulation and bistability in Bacteria subtilis, the reconstruction of gene networks, antimicrobial peptides, especially antibiotics, pathogenesis mechanisms, cell wall anchoring, controlled gene expressionsystems, the subcellular localization of protein, stress respons,quorum sensing, regulation of the C- and N-metabolism , natural gene transfer methodologies, plant-biocontrol by Bacilli and Biotechnology applications.

Research for industry

• 2014 – 2017 Corbion, Corbion Thermophiles. Prime investigator €530k
• 2010-2013 Purac, Competence in industrial Bacillus strains. Prime investigator €420k
• 2004 – 2007 DSM Bakery Ingredients B.V. Sense: Screening for protein secertion using secretion stress indicators. Prime investigator €640k
• 2001 – 2005 Frico + DSM Directing Starters Together 2 (several partners). Prime investigator €554k
• 2000 – 2006 Intervet International B.V. Expression of heterologous proteins in Bacillus. Prime investigator €433k

Research by Bachelor and Master students

From 2008 Kuipers is supervisor, coach and coordinator of the iGEM student team Groningen. iGEM is a world wide competition in the field of synthetic biology between teams of students from all over the world. The team from Groningen won in the annual in Boston (United States) organized international competition, gold medals in 2008, 2009 (also finalist), 2010, 2011, 2012 (also world champion), 2013 en (2014).
In 2012, when the team from Groningen became world champion, the research concerned a study of an alternative method to determine whether food is spoiled: the Food warden . This method makes use of genetic engineered bacteria responsive to the volatiles of the decomposing meat. A pigment makes the decomposition visible.
In 2015 again a gold medal was won by the student team of the University of Groningen with the Blue energy project. The team developed a revolutionairy biological membrane on base of Bacteria for the generation of blue energy. This is elektricity available from the difference in the salt concentration between seawater and fresh water.

Publications

Prof. dr. O.P. Kuipers published 365 articles in scientific papers, 2 books and 18 chapters in books. 34 Publicaties appeared in 2015. Kuipers articles have been cited over 22.148 times and he has a H-index of 75 and an i10 index of 270. This means that 75 of his articles have been cited at least 75 times and that 270 articles have been cited more than 10 times.

• An overview of the most significant publications of Oscar Kuipers.
• Kuipers, O.P., Thunnissen M.M.G.M., de Geus P., Dijkstra B.W., Drenth J., Verheij, H.M., de Haas G.H. (1989) Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. Science 244, 82-85.
• Thunnissen, M.M.G.M., AB, E., Kalk, K.H., Drenth, J., Dijkstra, B.W., Kuipers, O.P., Dijkman, R., de Haas, G.H. & Verheij, H.M. (1990) X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor. Nature 347, 689-691.
• Kuipers, O.P., Boot, H.J. & de Vos, W.M. (1991) Improved site-directed mutagenesis method using PCR. Nucleic Acids Research 19 (16), 4558.
• Kuipers, O.P., Rollema, H.S., Yap, W.M.G.J., Boot, H.J., Siezen, R.J. & de Vos, W.M. (1992) Engineering dehydrated amino acid residues in the antimicrobial peptide nisin. Journal of Biological Chemistry 267, 24340-24346.
• Kuipers, O.P., Beerthuyzen, M.M., de Ruyter, P.G.G.A., Luesink, E.J. & de Vos, W.M. (1995) Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction. Journal of Biological Chemistry 270, 27299-27304.
• de Ruyter, P.G.G.A., Kuipers, O.P. & de Vos (1996) Controlled gene expression systems for Lactococcus lactis using the food-grade inducer nisin. Applied Environmental Microbiology 62, 3662-3667 .
• Breukink, E.J., Wiedemann, I., van Kraaij, C., Kuipers, O.P., Sahl, H.-G. & de Kruijff, B. (1999) Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286, 2361-2364.
• Hasper, H.E., Kramer, N.E., Smith, J.L., Hillman, J.D., Zachariah, C., Kuipers, O.P., de, Kruijff, B. & Breukink, E. (2006) An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313, 1636-1637.
• Kloosterman, T.G., van der Kooi-Pol, M.M., Bijlsma, J.J. & Kuipers, O.P. (2007) The novel transcriptional regulator SczA mediates protection against Zn(2+) stress by activation of the Zn(2+)-resistance gene czcD in Streptococcus pneumoniae. Mol. Microbiol. 65, 1049-1063.
• Martinez, B., Zomer, A.L., Rodriguez, A., Kok, J. & Kuipers, O.P. (2007) Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the Lactococcal two-component system CesSR. Mol. Microbiol. 64, 473-486.
• Rink, R., Wierenga, J., Kuipers, A., Kluskens, L.D., Driessen, A.J., Kuipers, O.P. & Moll, G.N. (2007) Production of Dehydroamino Acid-Containing Peptides by Lactococcus lactis. Appl. Environ. Microbiol. 73, 1792-1796.
• Smits, W.K., Bongiorni, C., Veening, J.W., Hamoen, L.W., Kuipers, O.P. & Perego, M. (2007) Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis. Mol. Microbiol. 65, 103-120.
• Wegmann, U., O'connell-Motherway, M., Zomer, A., Buist, G., Shearman, C., Canchaya, C., Ventura, M., Goesmann, A., Gasson, M.J., Kuipers, O.P., van Sinderen, D. & Kok, J. (2007) The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363. J. Bacteriol. 189, 3256-3270.
• Brouwer, R.W., Kuipers, O.P. & Hijum, S.A. (2008) The relative value of operon predictions. Brief. Bioinform. 9, 367-375.
• Buist, G., Steen, A., Kok, J. & Kuipers, O.P. (2008) LysM, a widely distributed protein motif for binding to (peptido)glycans. Mol. Microbiol. 68, 838-847.
• Veening, J.W., Igoshin, O.A., Eijlander, R.T., Nijland, R., Hamoen, L.W. & Kuipers, O.P. (2008) Transient heterogeneity in extracellular protease production by Bacillus subtilis. Mol. Syst. Biol. 4, 184.
• Veening, J.W., Smits, W.K. & Kuipers, O.P. (2008) Bistability, epigenetics, and bet-hedging in bacteria. Annu. Rev. Microbiol. 62, 193-210.
• Veening, J.W., Stewart, E.J., Berngruber, T.W., Taddei, F., Kuipers, O.P. & Hamoen, L.W. (2008) Bet-hedging and epigenetic inheritance in bacterial cell development. Proc. Natl. Acad. Sci. U. S. A. 105, 4393-4398.
• Kovacs, A.T., Smits, W.K., Mironczuk, A.M. & Kuipers, O.P. (2009) Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries. Environ. Microbiol. 11, 1911-1922.
• Lubelski, J., Khusainov, R. & Kuipers, O.P. (2009) Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin. J. Biol. Chem. 284, 25962-25972.
• van Hijum, S.A., Medema, M.H. & Kuipers, O.P. (2009) Mechanisms and evolution of control logic in prokaryotic transcriptional regulation. Microbiol. Mol. Biol. Rev. 73, 481-509.
• de Jong A., van Heel, A.J., Kok, J. & Kuipers, O.P. (2010) BAGEL2: mining for bacteriocins in genomic data. Nucleic Acids Res. 38, W647-W651.
• de Jong, I.G., Veening, J.W. & Kuipers, O.P. (2010) Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation. J. Bacteriol. 192, 2053-2067.
• Majchrzykiewicz, J.A., Lubelski, J., Moll, G.N., Kuipers, A., Bijlsma, J.J., Kuipers, O.P. & Rink, R. (2010) Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob. Agents Chemother. 54, 1498-1505.
• de Jong, I.G., Haccou, P. & Kuipers, O.P. (2011) Bet hedging or not? A guide to proper classification of microbial survival strategies. Bioessays 33, 215-223.
• Eijlander, R.T., Abee, T. & Kuipers, O.P. (2011) Bacterial spores in food: how phenotypic variability complicates prediction of spore properties and bacterial behavior. Curr.Opin.Biotechnol. 22, 180-186.
• Khusainov, R., Heils, R., Lubelski, J., Moll, G.N. & Kuipers, O.P. (2011) Determining sites of interaction between prenisin and its modification enzymes NisB and NisC. Mol.Microbiol. 82, 706-718.
• Kloosterman, T.G. & Kuipers, O.P. (2011) Regulation of arginine acquisition and virulence gene expression in the human pathogen Streptococcus pneumoniae by transcription regulators ArgR1 and AhrC. J.Biol.Chem. 286, 44594-44605.
• Kovacs, A.T. & Kuipers, O.P. (2011) Rok regulates yuaB expression during architecturally complex colony development of Bacillus subtilis 168. J.Bacteriol. 193, 998-1002.
• Price, C.E., Zeyniyev, A., Kuipers, O.P. & Kok, J. (2011) From meadows to milk to mucosa - adaptation of Streptococcus and Lactococcus species to their nutritional environments. FEMS Microbiol.Rev. 36(5): 949-7
• Shafeeq, S., Kloosterman, T.G. & Kuipers, O.P. (2011) Transcriptional response of Streptococcus pneumoniae to Zn(2+) limitation and the repressor/activator function of AdcR. Metallomics 3, 609-618.
• Shafeeq, S., Yesilkaya, H., Kloosterman, T.G., Narayanan, G., Wandel, M., Andrew, P.W., Kuipers, O.P. & Morrissey, J.A. (2011) The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae. Mol.Microbiol. 81, 1255-1270.
• van Heel, A.J., Montalban-Lopez, M. & Kuipers, O.P. (2011) Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans. Expert Opin.Drug Metab.Toxicol. 7, 675-680.
• Arnison, P.G., Bibb, M.J., Bierbaum, G., Bowers, A.A., Bugni, T.S., Bulaj, G., Camarero, J.A., Campopiano, D.J., Challis, G.L., Clardy, J., Cotter, P.D., Craik, D.J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P.C., Entian, K.D., Fischbach, M.A., Garavelli, J.S., Goransson, U., Gruber, C.W., Haft, D.H., Hemscheidt, T.K., Hertweck, C., Hill, C., Horswill, A.R., Jaspars, M., Kelly, W.L., Klinman, J.P., Kuipers, O.P., Link, A.J., Liu, W., Marahiel, M.A., Mitchell, D.A., Moll, G.N., Moore, B.S., Muller, R., Nair, S.K., Nes, I.F., Norris, G.E., Olivera, B.M., Onaka, H., Patchett, M.L., Piel, J., Reaney, M.J., Rebuffat, S., Ross, R.P., Sahl, H.G., Schmidt, E.W., Selsted, M.E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Sussmuth, R.D., Tagg, J.R., Tang, G.L., Truman, A.W., Vederas, J.C., Walsh, C.T., Walton, J.D., Wenzel, S.C., Willey, J.M., & van der Donk, W.A. (2012). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30, 108-60.
• de Jong, I.G., Veening, J.W., & Kuipers, O.P. (2012). Single cell analysis of gene expression patterns during carbon starvation in Bacillus subtilis reveals large phenotypic variation. Environ. Microbiol. 14, 3110-21.
• Marciniak, B.C., Pabijaniak, M., de Jong, A., Duhring, R., Seidel, G., Hillen, W., & Kuipers, O.P. (2012). High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis. BMC Genomics 17;13:401
• Montalban-Lopez, M., Zhou, L., Buivydas, A., van Heel, A.J., & Kuipers, O.P. (2012). Increasing the success rate of lantibiotic drug discovery by Synthetic Biology. Expert Opin. Drug Discov. 7, 695-709.
• Boonstra, M., de Jong, I.G., Scholefield, G., Murray, H., Kuipers, O.P. & Veening, J.W. (2013) Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis. Mol.Microbiol. 87, 925-938.
• van Heel, A.J., de Jong, A., Montalban-Lopez, M., Kok, J. & Kuipers, O.P. (2013) BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides. Nucleic Acids Res. 41, W448-53.
• van Heel, A.J., Mu, D., Montalban-Lopez, M., Hendriks, D. & Kuipers, O.P. (2013) Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes. ACS Synth.Biol. 2, 397-404.
• Eijlander, R.T., de Jong, A., Krawczyk, A.O., Holsappel, S. & Kuipers, O.P. (2014) SporeWeb: an interactive journey through the complete sporulation cycle of Bacillus subtilis. Nucleic Acids Res. 42, D685-91.
• Puri, P., Eckhardt, T.H., Franken, L.E., Fusetti, F., Stuart, M.C., Boekema, E.J., Kuipers, O.P., Kok, J. & Poolman, B. (2014) Lactococcus lactis YfiA is necessary and sufficient for ribosome dimerization. Mol.Microbiol. 91, 394-407.
• Siebring, J., Elema, M.J., Drubi Vega, F., Kovacs, A.T., Haccou, P. & Kuipers, O.P. (2014) Repeated triggering of sporulation in Bacillus subtilis selects against a protein that affects the timing of cell division. ISME J. 8(1): 77–87
• van Gestel .; Weissing F.J.; Kuipers O.P.; Kovacs A.T. (2014) Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms. ISME J 8(10):2069-79
• Solopova A.; van Gestel J.; Weissing F.J.; Bachmann H.; Teusink B.; Kok J.; Kuipers O.P. (2014) Bet-hedging during bacterial diauxic shift. Proc Natl Acad Sci U S A 20;111(20):7427-32.
• Smith C.M.; Sandrini S.; Datta S.; Freestone P.; Shafeeq S.; Radhakrishnan P.; Williams G.; Glenn S.M.; Kuipers O.P.; Hirst R.A.; Easton A.J.; Andrew P.W.; (2014) Respiratory syncytial virus increases the virulence of Streptococcuspneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. Am J Respir Crit Care Med 190(2):196-207
• Overkamp W.; Ercan O.; Herber M.; van Maris A.J.; Kleerebezem M.; Kuipers O.P. (2015) Physiological and cell morphology adaptation of Bacillus subtilis at near-zero specific growth rates: a transcriptome analysis. Environ Microbiol. 17(2):346-63
• Kuipers O.P. (2015) Back to nature: a revival of natural strain improvement methodologies. Microb Biotechnol. 8(1):17-8.
• Zhou L., van Heel A.J., Kuipers O.P. (2015) The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity. Front. Microbiology 29:6:11
• Afzal M., Shafeeq S., Kuipers O.P. (2015) Ascorbic acid-dependent gene expression in Streptococcus pneumoniae and the activator function of the transcriptional regulator UlaR2. Front Microbiology 11:6:11
• Mu D., Montalbán-López M., Deng J., Kuipers O.P. (2015) Substrate selectivity of the lantibiotic reductase LtnJ assessed by a collection of nisin derivatives as substrate. Appl Environ Microbiol 81(11):3679-87
• Detert Oude Weme R.G., Kovács Á.T., de Jong S.J., Veening J.,. Siebring J., Kuipers O.P. (2015) Single cell FRET analysis for the identification of optimal FRET-pairs in Bacillus subtilis using a prototype MEM-FLIM system. PLoS One.17;10(4)
• Grimbergen A.J., Siebring J., Solopova A., Kuipers O.P. (2015) Microbial bet-hedging: the power of being different. Curr Opin Microbiol. 26;25:67-72
• de Jong A., van der Meulen S., Kuipers O.P., Kok J. T-REx: Transcriptome analysis webserver for RNA-seq Expression data. BMC Genomics. 2015 Sep 3;16:663.
• Medema M.H., Kottmann R., Yilmaz P., Cummings M., Biggins J.B., Blin K., de Bruijn I., Chooi Y.H., Claesen J., Coates R.C., Cruz-Morales P., Duddela S., Düsterhus S., Edwards D.J., Fewer D.P., Garg N., Geiger C., Gomez-Escribano J.P., Greule A., Hadjithomas M., Haines A.S., Helfrich E.J., Hillwig M.L., Ishida K., Jones A.C., Jones C.S., Jungmann K., Kegler C., Kim H.U., Kötter P., Krug D., Masschelein J., Melnik A.V., Mantovani S.M., Monroe E.A., Moore M., Moss N., Nützmann H.W., Pan G., Pati A., Petras D., Reen F.J., Rosconi F., Rui Z., Tian Z., Tobias N.J., Tsunematsu Y., Wiemann P., Wyckoff E., Yan X., Yim G., Yu F., Xie Y., Aigle B., Apel A.K., Balibar C.J., Balskus E.P., Barona-Gómez F., Bechthold A., Bode H.B., Borriss R., Brady S.F., Brakhage A.A., Caffrey P., Cheng Y.Q., Clardy J., Cox R.J., De Mot R., Donadio S., Donia M.S., van der Donk W.A., Dorrestein P.C., Doyle S., Driessen A.J., Ehling-Schulz M., Entian K.D., Fischbach M.A., Gerwick L., Gerwick W.H., Gross H., Gust B., Hertweck C., Höfte M., Jensen S.E., Ju J., Katz L., Kaysser L., Klassen J.L., Keller N.P., Kormanec J., Kuipers O.P., Kuzuyama T., Kyrpides N.C., Kwon H.J., Lautru S., Lavigne R., Lee C.Y., Linquan B., Liu X., Liu W., Luzhetskyy A., Mahmud T., Mast Y., Méndez C., Metsä-Ketelä M., Micklefield J., Mitchell D.A., Moore B.S.,Moreira L.M., Müller R., Neilan B.A., Nett M., Nielsen J., O'Gara F., Oikawa H., Osbourn A., Osburne M.S., Ostash B., Payne S.M., Pernodet J.L., Petricek M., Piel J., Ploux O., Raaijmakers J.M., Salas J.A., Schmitt E.K., Scott B., Seipke R.F., Shen B., Sherman D.H., Sivonen K., Smanski M.J., Sosio M., Stegmann E., Süssmuth R.D., Tahlan K., Thomas C.M., Tang Y., Truman A.W., Viaud M., Walton J.D., Walsh C.T., Weber T., van Wezel G.P., Wilkinson B., Willey J.M., Wohlleben W., Wright G.D., Ziemert N., Zhang C., Zotchev S.B., Breitling R., Takano E., Glöckner F.O.; Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Aug 18;11(9):625-31. doi: 10.1038/nchembio.1890. PubMed PMID: 26284661.
• Manzoor I., Shafeeq .S, Kloosterman T.G., Kuipers .O.P; Co(2+)-dependent gene expression in Streptococcus pneumoniae: opposite effect of Mn(2+) and Co(2+) on the expression of the virulence genes psaBCA, pcpA, and prtA. Front Microbiol. 2015 Jul 24;6:748. doi: 10.3389/fmicb.2015.00748.
• Grau R.R., de Oña P., Kunert M., Leñini C., Gallegos-Monterrosa R., Mhatre E., Vileta D., Donato V., Hölscher T., Boland W., Kuipers O.P., Kovács Á.T.; A Duo of Potassium-Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis. MBio. 2015 Jul 7;6(4):e00581.

Main national scholarships, grants and subsidies

Included are the research Grants and subsidies since 2000. The amounts were made available to the research group of Professor Kuipers.

Subsidies of the Netherlands Organisation for Scientific Research (NWO)

• 2000 – 2001 NWO Middelgroot DNA microarray equipment: printing and analyzing. €510k
• 2001 – 2005 NWO-ALW To become competent or not: an inquiry into the molecular basis of bacterial differentiation. (publication) Prime investigator €140k
• 2002 – 2006 NWO-STW Origin of variability in stress resistance of bacterial spores. Mede Prime investigator €212k
• 2002 – 2006 NWO-CW Computational genomics of prokaryotes. Partly Prime investigator €171k
• 2003 – 2007 NWO- ALW Secretome Dynamics. Prime investigator €328k
• 2005 – 2008 NWO-STW Enzymatic synthesis of thioether-ring-containing (poly) peptides for enhancing stability and modulating bioactivity. Prime investigator €175k
• 2006 – 2010 NWO-ALW Mechanism and substrate specificity of the dehydratase of the lantibiotic nisin. Prime investigator €201k
• 2007 – 2011 NWO-ALW The transition from growing to non-growing Bacillus subtilis cells. Prime investigator €125k
• 2008 – 2011 NWO-ALW Elucidation of the mechanism of lantibiotic biosynthesis. Prime investigator €210k
• 2008 – 2012 NWO-STW Optimizing growth rate and cell mass of lactic acid bacteria. Mede Prime investigator €226k
• 2009 – 2012 NWO-EW The evolution of stochastic heterogeneous gene expression. Prime investigator €198k
• 2009 – 2013 NWO-STW Awakening the Sleeping Lantibiotics. Prime investigator €262k
• 2009 – 2013 NWO-STW Understanding preculture-dependent gene expression. Mede Prime investigator €227k
• 2009 – 2014 NWO-STW Lipid engineering and modulation of proetein secerteion in Bacillus. Prime investigator €311k
• 2011 – 2014 NWO-ALW Purification of Peptide Antimicrobials and Thioether-Stabilized Molecules Produced In Vivo by Lantibiotic Modification Machineries. Prime investigator €272k
• 2011 – 2015 NWO-STW Molecular determinants of phenothtypic heterogeneity in Baccilus subtilis. Prime investigator €500k
• 2012 – 2013 NWO Medium: Spinning Disc Fluorescence Microscope. Hoofdaanvrager €400k
• 2012 – 2016 NWO-STW Lanthexpress. Co-PI €207k
• 2014 – 2016 NWO-ALW Experimental evolution of bet-hedging strategies for spore formation in Bacillus subtilis. Prime investigator €276k
• 2014 – 2019 NWO-CW SynGenoPep. Partly Prime investigator €240k
• 2015 NWO-CW 'Silver Hourglass ”Lanthiopharma New Chemical Structure Lantibiotica. Prime investigator €19k
• 2015 – 2018 NWO-STW Selection of micobial cells with increased product-yield for industrial fermentations. Partly prime investigator €238k

Grants and subsidies of the Dutch Government

• 2002 – 2006 SenterNovem (Ministry of Economic Affairs (Netherlands)) Comparative and predictive transcriptome analysis of Gram-positive bacteria for enhanced food quality and food safety. Prime investigator €846k
• 2004 – 2008 SenterNovem (Ministry of Economic Affairs (Netherlands) Streptococcus pneumoniae: Genomic array footprinting. Partly prime investigator €621k
• 2005 – 2008 SenterNovem (Ministry of Economic Affairs (Netherlands) Metabolic engineering for cost efficient production of D (-) lactic acid, a raw material for biodegradable plastic polylactic acid.' ' Prime investigator €322k
• 2011 Simon Stevin Meesterschap (Science and Technology Award of STW, NWO, the Netherlands) €500k
• 2012 – 2014 “Samenwerkingsverband Noord Nederland (SNN)” of the (provinces of Groningen, Friesland en Drenthe) LanthioPEP-RUG. Partly prime investigator €104k
• 2014 – 2019 Agentschap NL ([Ministry of Economic Affairs) BE-Basic: Natural transfer of DNA among lactic acid bacteria for improved starters. Prime investigator €1027k

Netherlands Genomics Initiative (NGI)

• 2008 – 2013 NGI Kluyver Centre: Experimental evolution of Lactococcus. Prime investigator €337k
• 2009 – 2013 NGI KCII 3.2.01 Regulation of N-metabolism in Bacillus. Prime investigator €337k
• 2009 – 2013 NGI KC Characterisation of cellular metabolism under zero-growth. Prime investigator €337k

Top Institute Food and Nutrition Foundation (TIFN)

• 2009 – 2011 TIFN C-1056 Sporulation Bacillus cereus. Partly prime investigator €283k
• 2011 – 2014 TIFN SP002 Sporulation and germination of Bacilli. Partly prime investigator €800k
• 2011 – 2014 TIFN BG001. Partly prime investigator €235k
• 2011 – 2015 TIFN Modeling of Sporulation in industrial Bacilli. Partly prime investigator €387k

Main international scholarships and grants

• 2001 – 2004 EU FP5 Nutra Cells, Partly prime investigator and work package leader, €242k
• 2001 – 2005 EU FP5 Express Fingerprints Partly prime investigator and work package leader, €408k
• 2004 – 2008 EU FP6 Bacell Health Partly prime investigator and work package leader, €224k
• 2004 – 2008 EU FP6 Tat Machine. Partly prime investigator €246k
• 2009 – 2012 EU FP7 Pneumopath: core metabolism in Streptococcus pneumoniae. Partly prime investigator €158k
• 2006 – 2010 SYSMO1 Grant Bacillus subtilis Systems Biology. Transnational grant funded through NWO-ALW. Partly prime investigator €180k
• 2010 – 2013 SYSMO2 Grant Modelling carbon. Transnational grant funded through NWO-ALW. Partly prime investigator €180k
• 2010 – 2013 SYNMOD Grant (ESF Eurocores international project, 5 groups) funded through NWO- ALW. Prime investigator €242k
• 2013 – 2017 EU FP7 Bachberry. Partly prime investigator €280k
• 2013 – 2017 EU FP7 SynPeptide. Partly prime investigator and work package leader €1050k

Memberships and commissions

Dutch memberships and commissions

• 2015 Jury member for the Leeuwenhoek Medal, the Royal Dutch Society for Microbiology (KNVM), Netherlands
• 2015 Member of the organizing committee and the program committee of the FEMS Congress 2015 in Maastricht
• 2013 Program Committee JSTP Agriculture & Food: How to Feed the World?
• 2012- present Member of the Scientific Board of the Royal Dutch Society for Microbiology (KNVM)
• 2011 - present Elected member of the Royal Netherlands Academy of Arts and Sciences (KNAW)
• 2011-2014 Managementteam, Kluyver Centre for Genomics of Industrial Fermentation, Schedule 3, Netherlands
• 2010 – 2012 President “Foundation Biotechnology Netherlands” (SBN), Netherlands
• 2009 President STW, NWO Veni Committee, Netherlands Organisation for Scientific Research (NWO)
• 2008, '12, '15 Member of the Open Program Committee of NWO Earth and Life Sciences NWO-ALW)
• 2006 - 2008 Chairman, NWO-ALW Genetics
• 2006 – 2008 Consultant, Purac, Gorinchem, Netherlands
• 2005 Member of the Rosalind Franklin Selection, University of Groningen
• 2002 – 2007 Consultant, BioMade, Netherlands
• 2004 Member Policy Advisory Committee, NWO Thematic Programme, Netherlands
• 2004 - 2006 President, Dutch Biotechnology Association (NBV), 1100 members
• 2003 - 2005 Board of NWO-ALW-Genetics
• 2003 - 2006 member of the Policy Advisory Committee of the Dutch Organisation for Scientific Research, Earth and Life Sciences (NWO-ALW)
• 2003 – 2004 Vice president, Dutch Biotechnology Society
• 2001 - 2008 Member assessment commission of the Netherlands Genomics Initiative
• 2000 - 2004 Member of the NWO-ALW-Medium and Large Equipment Committee
• 2000 - 2003 Program committee member Bioinformatics, NWO-ALW
• 2000 Member Advisory Committee Politicians in the United Kingdom, on the role of the transcriptome when assessing the safety of genetically modified organisms
• 1999-2003 Board member of the European Federation of Biotechnology (EFB), workgroup Applied Genomics.

Foreign memberships and commissions

• 2015 Elected board member of the European Academy of Microbiology (EAM)
• 2015 Member of the Advisory Board Horizon 2020 EU Project on Clostridia (PI: Nigel Minton)
• 2015 Jury member for the Lwoff Medal of the “Federation of European Microbiological Societies (FEMS)”
• 2014, 2016 Member of the evaluation panel, ERC Starting Grants, European Commission, Brussels, Belgium
• 2014 Member of the jury of the "Centre de Biochimie structurale Montpellier (CBS), France
• 2013 Elected member of the European Academy of Microbiology (EAM)‘'
• 2013 Member of the Board for the evaluation of the department Systems Biology, Technical University of Denmark (DTU), Copenhagen, Denmark
• 2012 Member of the evaluation program "Singe Cells", Deutsche Forschungsgemeinschaft (DFG), Munich, Germany
• 2011, '12, '15 Member of the evaluation committee Irish Research Council IRCSET and SCI, Ireland
• 2011 President of the Jury of iGEM 2011, Amsterdam
• 2010, 2015 Member evaluation committee of the department microbiology of the Pasteur Institute, Paris, France
• 2008 Member evaluation committee Spanish National Research Council (CSIC), Madrid, Spain
• 2008 Member evaluation committee of the Eesti Institute (Ests Instituut), Tallinn, Estland
• 2008 Member evaluation committee of the projects of the Irish Science Council, Cork, Ireland
• 2005 Member evaluation committee of the LMC Copenhagen (Centre for Advanced Food Studies, a consortium of several universities and research institutes), Denmark
• 2000 Member Advisory Committee Politicians in the United Kingdom, on the role of the transcriptome when assessing the safety of genetically modified organisms
• 1999-2003 Board member of the European Federation of Biotechnology (EFB), working group Applied Genomics.

Membership of editorial committees

• 2014 - present Member of Editorial Board,PLOS One
• 2014 - present Member of Editorial Board, FEMS Microbiology Reviews
• 2010 Guest editor Food Biotechnology, Current Opinion in Biotechnology
• 2000 - 2009 Editorial Board, FEMS Microbiology Letters
• 2005, 1999 Guest editor, FEMS Microbiology Reviews
• 2007 – present Member of Editorial Board, Microbial Biotechnology
• 2007 – present Member of Editorial Board, Recent Patents in Biotechnology
• 2007 – 2010 Member of Editorial Board –advisory board, Molecular Microbiology
• 1998 – 2002 Member of Editorial Board, Journal of Applied Microbiology

Membership of professional associations

• Member of the American Society for Microbiology (ASM)
• Member of the Nederlandse Vereniging voor Biochemie en Moleculaire Biologie (NVBMB) (Dutch Society for Biochemistry and Molecular Biology)
• Member of the Koninklijke Vereniging van Microbiologie (KNVM) (Royal Society for Medical Microbiology)
• Board member of the Koninklijke Vereniging voor Medische Microbiologie (KVMM)
• Member and former president of the Nederlandse Vereniging voor Microbiologie (NBV) (Dutch Society for Microbiology).

*Category:1956 births *Category:Living people *Category:Dutch chemists *Category:Organic chemists *Category:Biotechnologists *Category:Members of the Royal Netherlands Academy of Arts and Sciences *Category:University of Groningen faculty